Overall, the results that pretreatment with baicalein and Lipo-1 could reduce the production of 4-HNE, the mRNA expression of PTGS2, and the expression of 12/15-LOX and up-regulate the expression of GPX4 in FeCl3-induced posttraumatic epileptic seizures further support that baicalein could exert neuroprotective effects in FeCl3-induced epileptic seizures by inhibiting 12/15-LOX-related ferroptosis. The gene discussed is PTGS2; the disease is Seizure.