The expressions of mPGES-1 and COX-2 are induced upon treatment with IL-1β in the NSCLC cell line A549 (Jakobsson et al., 1999), and this system is appreciated as a good model to study the modulation of the COX-2/mPGES-1/PGE2 pathway. The gene discussed is PTGES; the disease is non-small cell lung carcinoma.