CCL2 and Alzheimer disease: CCL2 or monocyte chemoattractant protein 1 (MCP-1), mostly produced by glial cells, seems to have a detrimental role in AD pathogenesis, as its overexpression has been found in brain (Sokolova et al., 2009; Vukic et al., 2009), mature senile plaques, microglia, and microvessels of AD patients (Grammas and Ovase, 2001).