Inhibition of the potassium current mediated by hEag1 leads not only to a clear anti-proliferative activity in vitro but also to a decrease in tumor cell growth in vivo (ovarian, breast, cervical, colon, pancreas carcinoma, melanoma, and fibrosarcoma) (Gómez-Varela et al., 2007). Here, KCNH1 is linked to neoplasm.