Prior studies suggest that NPTX2 may be a “resilience factor,”, based on its ability to balance excitation/inhibition (Chang et al., 2010; Pelkey et al., 2015) and the observed preservation of NPTX2 levels in brains of individuals who were cognitively normal at death but had neuropathological evidence of AD (sometimes referred to as asymptomatic AD) (Xiao et al., 2017). This evidence concerns the gene NPTX2 and Alzheimer disease.