Higher NPTX2 was associated with higher CSF levels of both total tau (t-tau, a marker of general neurodegeneration) and phosphorylated tau (p-tau, a marker of neurofibrillary tau tangles) within both cognitively normal and AD-dementia patients, but not with CSF abeta 1-42 levels (Xiao et al., 2017). Here, MAPT is linked to Alzheimer disease.