SNCA and proteostasis deficiencies: Neuropathologic changes in the aging brain often include changes in extracellular amyloid-β (Aβ) in plaques, increases in intracellular hyperphosphorylated tau and neurofibrillary tangles (NFTs), with α-synuclein, TDP-43 proteinopathy, and hippocampal sclerosis occurring less frequently (Rahimi and Kovacs, 2014).