Particularly, the acetylation of NF-κB/RelA at Lys310 activates the NF-κB-dependent response, a well-studied epigenetic regulation in post-ischemic injury (Lanzillotta et al., 2010), with consequent 1B/(–)IRE DMT1 up-regulation in models of differentiated human neuroblastoma and in mouse primary cortical neurons exposed to OGD, or transient middle cerebral artery occlusion (tMCAO) (Ingrassia et al., 2012), and also in undifferentiated P19 embryonic carcinoma cells (Paradkar and Roth, 2006a,Paradkar and Roth, 2006b). This evidence concerns the gene NFKB1 and neuroblastoma.