SLC11A2 and neuroblastoma: Tian et al. (2018) also showed how the down-regulation of DMT1, with reduced iron uptake and decreased Aβ(1–42) peptide secretion, occurs after transient overexpression of Ndfip1 in SH-SY5Y human neuroblastoma cells stably over-expressing APPsw. Accordingly, in immortalized microglia cells, the Aβ (1–42) treatment induced pan-DMT1 up-regulation (McCarthy et al., 2018).