PRKN and neuroblastoma: In fact, the Parkin-dependent post-translational degradation of 1B DMT1 isoform was shown to influence metal transport in SH-SY5Y, human neuroblastoma cells, overexpressing wild-type and mutant forms (Park-T240R) of human Parkin, while 1A DMT1 isoform resulted unaffected (Roth et al., 2010).