Interestingly, 59Fe-NTBI uptake was impaired in ZIP14/SLC39A14 null mice when fed with iron-loaded diet or crossed with mouse models of hereditary hemochromatosis, while DMT1 siRNA reduced iron loading in a mouse model of hereditary hemochromatosis (Wang et al., 2019), thus highlighting the role of both NTBI transporters in the complex homeostasis of iron overload, with cerebral implications. This evidence concerns the gene SLC39A14 and hereditary hemochromatosis.