Again, in MES23.5 dopaminergic neurons and in the substantia nigra of the 6-OHDA lesioned rats, as a PD model, iron accumulation was associated to NMDA receptors activation, through the up-regulation of (+)IRE DMT1 and down-regulation of the iron exporter ferroportin (FPN1) (Xu et al., 2018). This evidence concerns the gene SLC11A2 and Parkinson disease.