SLC11A2 and Alzheimer disease: Furthermore, several reports have recently highlighted that, during aging, iron and DMT1 accumulate in the frontal cortex of the APPSWE/PS1ΔE9 transgenic mouse model (Xian-hui et al., 2015), where both (–)/(+) IRE DMT1 were also increased in the cortex and hippocampus compared with wild type-control (Zheng et al., 2009), potentially contributing to increasing to the risk of developing AD.