Analyzing and comparing postmortem brain inferior parietal lobule tissue from patients diagnosed with mild cognitive impairment (MCI), AD, and healthy matched controls, Tramutola et al. (2015) showed that an increase in AKT and PI3K (p85 subunit) phosphorylation occurs in MCI and AD patients, coupled with mTOR hyperactivation. This evidence concerns the gene MTOR and Alzheimer disease.