Mutations leading to a loss-of-function in the TANK-binding kinase (TBK)1 phenotype also lead to an increased risk of developing ALS and FTD due to autophagy impairment (Cirulli et al., 2015; Freischmidt et al., 2015; Cui et al., 2018). The gene discussed is TBK1; the disease is amyotrophic lateral sclerosis.