Proof-of-principle retrospective studies of standard of care in combination with an EGFR and vascular endothelial growth factor (VEGF) inhibitor have been completed in mutant KRAS-driven GEMMs of non-small-cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC).38 These models successfully predicted clinical efficacy. The gene discussed is KRAS; the disease is non-small cell lung carcinoma.