As expected, SOX2 overexpression in METTL3-knockdown and control CRC cells (Fig. 3g and Additional file 6: Figure S3d) led to the increased sphere formation, and an apparent chemotherapy resistance phenotype (Figs. 3h-i, and Additional file 6: Figures S3e-f). This evidence concerns the gene METTL3 and colorectal carcinoma.