Considering the controversial conclusions of m6A and METTL3 in different cancer types, we believe that our current study has uncovered the underlying functions of WERs in CRC and showed the oncogenic role of METTL3 in promoting CRC stemness and metastasis, indicating the broad impact of METTL3 and m6A methylation on cancer development and precision therapy. This evidence concerns the gene METTL3 and colorectal carcinoma.