Increasing copeptin tertile was after adjustment for age, gender, and ethnicity significantly associated with elevated HbA1c, insulin, HOMA-IR, BMI, overweight, obesity, abdominal obesity, waist circumference, and decreased HDL, whereas the association between copeptin and fasting glucose and GGT, respectively, did not remain significant after multivariate adjustment (Table 2). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.