Their findings also suggested that E6-mediated inhibition of MAGI-1 function contributes to HPV pathology by perturbing tight junction assembly with concomitant stimulation of proliferation and inhibition of apoptosis, and the restoration of MAGI-1 expression in HPV-positive cervical tumor cells could induce cell growth arrest and apoptosis [22]. This evidence concerns the gene MAGI1 and uterine cervix neoplasm.