The case 1 with the non-frameshift insertion of both MAGI1 and SLC45A3 was died 27 months after the operation because of metastases to the liver and bone, while the molecular mechanism of MAGI1 and SLC45A3 to the cervical grade 2 tumor of this case is sill unknown and need to further study. The gene discussed is MAGI1; the disease is neoplasm.