AR and neoplasm: Moreover, two recent studies examined the antitumor activity of intense androgen deprivation strategies through neoadjuvant ADT plus abiraterone or ADT plus ENZ, with the goal of maximum AR inhibition to translate into greater tumor response.22, 23 Indeed, intratumoral androgens and AR transcriptional activity were nearly undetectable with treatment, however complete responses were limited, with some patients demonstrating disease progression.