The use of a myosin transgene to improve muscle function in an Acta1 mouse model for nemaline myopathy (Lindqvist et al. 2016) and the use of calcium sensitizers to improve diaphragm function (Ochala 2010; Doorduin et al. 2012) raise interesting perspectives for the future. The gene discussed is ACTA1; the disease is nemaline myopathy.