Notably, proteins involved in the pathogenesis of Alzheimer’s disease, amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), spinocerebellar ataxia (SCA) and Huntington’s disease (FUS, hnRNPA1, SMN, TAU and TDP43) are also SG components1. Here, TARDBP is linked to amyotrophic lateral sclerosis.