Interestingly, the beneficial effects of ELA on steatohepatitis are preserved in high-fat diet-fed double transgenic hApoE2/PPAR-α knock-out mice25, indirectly supporting the concept that PPAR-δ (also termed PPAR-β/δ) contributes to the anti-NASH effects of ELA. Here, PPARD is linked to metabolic dysfunction-associated steatohepatitis.