Both OCA + ELA 3 mg/kg (6.3 ± 0.4, p < 0.001 vs. vehicle) and OCA + ELA 10 mg/kg (6.0 ± 0.4, p < 0.001 vs. vehicle) effectively prevented further increases in Col1a1%-area in AMLN ob/ob-NASH mice, see Fig. 2C and Table 1. This evidence concerns the gene COL1A1 and metabolic dysfunction-associated steatohepatitis.