Accordingly, tumor cell-specific overexpression of the master-regulator c-Myc not only results in epithelial hyper-proliferation (when coinciding with increased expression of BH3 survival proteins) but also in expression of chemo-attracting CCL2, CCL3, and CCL5 and concomitant accumulation of mast cells16. The gene discussed is PROS1; the disease is neoplasm.