RAB43 and liver cancer: Interestingly, overexpression of Rab43A158T in another liver cancer cell line HepG2 with a high level of endogenous Rab43 expression has minimal effects on the growth, proliferation, colony formation and migration of the transfected HepG2 cells, indicating Rab43 A158T variant can substitute the function of WT Rab43 once wild type Rab43 is insufficient or lost completely.