Similarly, genes of the Notch signalling pathway are involved in both the monogenic migraine-related cerebrovascular disorder CADASIL (caused by pathogenic NOTCH3 variants) and common migraine, with GWAS loci identified near both the NOTCH4 receptor gene, and JAG1, which encodes Jagged1, a ligand of multiple Notch receptors. Here, JAG1 is linked to migraine disorder.