Furthermore, a systematic re-evaluation of the most promising candidate gene SNPs, including MTHFR C667T, and others previously found to be positively associated with migraine, showed no clear evidence for involvement in migraine using International Headache Genetics Consortium (IGHC) GWAS data for 5175 clinic-based migraineurs and 13,972 controls [195]. The gene discussed is MTHFR; the disease is migraine disorder.