In a retrospective study carried out in Japan on patients under therapy for an underlying hematological malignancy, Ebihara et al. concluded that the levels of PCT, but not those of CRP or presepsin, were significantly higher in the infection group than in the uninfected group (p < 0.03), indicating that PCT might be a more sensitive biomarker of infections, with findings that presepsin might have less diagnostic value in patients with neutropenia [64]. This evidence concerns the gene CALCA and Decreased total neutrophil count.