Uncontrolled studies demonstrate that immunosuppression using anti-cytokine directed therapies, such as tocilizumab 8mg/kg intravenous once, an anti-IL-6 receptor antibody (IL-6R antagonist), with or without corticosteroids, can reverse the life-threatening CRS in patients treated with CART-19 or blinatumomab [87]. This evidence concerns the gene IL6R and congenital rubella syndrome.