Among the phosphorylation targets of p38 there are several important transcription factors, including tumor protein p53, a phosphoprotein crucial in prevention of cancer formation [187], nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB), involved in the induction of antioxidant enzymes [188], and activating transcription factor 2 (ATF2), which regulates the transcription of various genes, including those involved in DNA damage response [189]. This evidence concerns the gene ATF2 and cancer.