Taken together, these results suggest that the potent cytotoxic effects of inhibiting both PI3K-AKT-mTOR and RAS-MAPK-ERK (alone or in combination with chemotherapeutic drugs) may increase steroid responsiveness, and should be investigated further, since they may represent an effective treatment in a subset of aggressive T-ALL. The gene discussed is PIK3CA; the disease is acute lymphoblastic leukemia.