Next, they showed that MK2206 dephosphorylates the glucocorticoid receptor NR3C1 in position S134, enabling its translocation into the nucleus and restoring steroid sensitivity in CCRF-CEM and MOLT3, two PTEN null, glucocorticoid-resistant T-ALL cell lines [31]. Here, NR3C1 is linked to acute lymphoblastic leukemia.