GJA1 and glioblastoma: In terms of glioblastoma biology pharmacological gap junction inhibition by carbenoxolone yielded additive effects on survival rates in temozolomide-treated orthotopic xenograft models in mice and a study of Munoz et al. could link resistance to standard chemotherapeutic agent temozolomide to intercellular connexin-43-mediated gap junction communication [27,39].