In the context of glioblastoma biology, Osswald et al. recently revealed gap junctions—composed of two connexin-43-based hexamers—to interconnect glioblastoma cells to a multicellular network allowing intercellular communication over long distances as well as enabling glioblastoma cells to fatally invade the healthy brain tissue [14,15]. This evidence concerns the gene GJA1 and glioblastoma.