A strong and significant correlation was also found between the expressions of NOS2 and the stemness marker SOX-2 (Sex-determining Region Y-Box 2), which resulted in being upregulated both in GBM cell lines, i.e., U-251MG, T98G, U-87 MG, U-373MG, LN229, and GBM primary cultures [16,17]. This evidence concerns the gene SOX2 and glioblastoma.