Even more recently, the emerging relevance of NOS2 as a prognostic factor in GBM malignancy has been further supported by our results, showing the crucial role of NOS2 expression in proliferation, clonogenic ability, migration, and NS generation, either in U87MG and T98G human glioma cell lines or GBM primary cultures [18]. The gene discussed is NOS2; the disease is central nervous system cancer.