There was suggestive evidence that higher fasting glucose (IVW p = 0.03), higher NAFLD (IVW p = 0.04) and higher alanine aminotransferase (IVW p = 0.05) were causally associated with higher liver iron content, but none of these associations reached our multiple testing threshold of being statistically significant. This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.