In diffuse large B-cell lymphoma (DLBCL), a subgroup called the activated B cell–like (ABC) DLBCL, are characterised by high IL-6 expression and STAT3 activity and, importantly, are selectively sensitive to JAK inhibition when compared to germinal center B-cell (GCB) DLBCL [86]. This evidence concerns the gene STAT3 and diffuse large B-cell lymphoma.