In cancer cells, EGFR signalling can induce STAT3 activation [66]; however, the data here identified that blockade of IL-6 or gp130 signalling using neutralising antibodies abolished STAT3 phosphorylation, suggesting that IL-6/gp130 is the major determinant for STAT3 phosphorylation in HPV+ cervical cancer cells. This evidence concerns the gene EGFR and cervical carcinoma.