Recent genetic and functional studies have shown that missense mutations in the TUBB3 gene disturb microtubule dynamics, impair kinesin interactions, and cause various neurological disorders characterized by defects in axon guidance and neuronal migration that include agenesis or hypoplasia of anterior commissure (AC), corpus callosum (CC), corticospinal tracts, and cranial nerves as well as malformations of cortical development (MCD) associated with neuronal migration and differentiation abnormalities [16, 17]. The gene discussed is TUBB3; the disease is nervous system disorder.