SH2B1 and Alzheimer disease: In agreement with the previous report [11], our results confirmed that expression levels of all three gene (PIAS1, RORA and SH2B1) were significantly downregulated in the PBMCs of the AD dogs by approximately 1.5-fold for RORA gene (P = 0.015) and 2-fold for both genes of PIAS1 (P = 0.036) and SH2B1 (P = 0.011) in comparison with the healthy dogs (Fig 2B).