TP53 and neoplasm: MYC is located in the 8q24 amplified regions in IPMNs (Table S6), which is one of the most frequently altered genes by CNAs in pan‐cancer analysis 42, 43 and whose amplification has been found in pancreatic acinar cell carcinomas.44, 45 The deletion region 17p13, which contains TP53 (Table S7) was also found to co‐occur with TP53 point mutations in all of the malignant samples (INC) with TP53 mutations (Figure 4D), which might be consistent with the two‐hit theory of tumor suppressor genes.