The amplification and deregulation of MYC have been reported in numerous cancer studies, and its key role in metabolism, cell cycle, the biogenesis of ribosomes, and consequently, in cell growth and proliferation makes it the perfect target and marker for malignancy in IPMN detection by PJD.49, 50, 51, 52 This finding, combined with the correlation of mutation burden with grade, has strong potential to predict the progression of IPMNs to malignancy, and exome sequencing or whole genome sequencing analysis of PJD is useful to assess the malignant risk of IPMNs. The gene discussed is MYC; the disease is pancreatic intraductal papillary-mucinous neoplasm.