Especially in tumor-initiating cells from the liver, an important function for the EpCAM protein has been well described [29]: an interrelation of EpCAM and Wnt in hepatocellular carcinomas was sustained with the finding that the EPCAM gene becomes transcriptionally activated by TCF-4, a member of the Lef family of transcription factors [29]. The gene discussed is EPCAM; the disease is hepatocellular carcinoma.