MSH2 and Lynch syndrome: Contrary to CTE, EPCAM-associated Lynch syndrome is not due to loss of EpCAM per se, but rather is due to monoallelic deletions of the 3′ end of the EPCAM gene in which the polyadenylation signal is lost leading to MSH2 promoter hypermethylation, read-through transcription of the EPCAM and MSH2 genes, and loss of MSH2 protein expression [16].