EGF and head and neck squamous cell carcinoma: Since EGFR signaling pathways promote EMT-characteristic phenotypic changes, the authors addressed whether EpEX could modulate EGF-dependent EMT in HNSCC cell lines and showed that soluble EpEX-Fc, acting as an EGF competitor for EGFR, counteracted EMT via repression of the EMTTF (Snail, ZEB1, and Slug) activation.