EPCAM and lung adenocarcinoma: Chromatin immunoprecipitation revealed an association of repressive epigenetic marks and methylation within the EPCAM promoter increased gradually as EPCAM expression decreased in three lung adenocarcinoma cell lines [36], whereas in ovarian cancer positive cell lines, epigenetic marks that indicate activated gene transcription were immunoprecipitated with EPCAM promoter sequences [37].