PIM1 and cancer: Treatment of human colon and lung cancer cell lines with the specific EpCAM antibody G8.8 showed a dose-dependent increase in proliferation and revealed that most deregulated genes were involved in cell cycle regulation (like LATS2, FOSL2 and PIM1), proliferation, cell growth, apoptosis (mainly GADD45 and PIM1) and other cancer related processes [67].