Since EGFR signaling pathways promote EMT-characteristic phenotypic changes, the authors addressed whether EpEX could modulate EGF-dependent EMT in HNSCC cell lines and showed that soluble EpEX-Fc, acting as an EGF competitor for EGFR, counteracted EMT via repression of the EMTTF (Snail, ZEB1, and Slug) activation. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.