MTOR and Huntington disease: It is worth to mention that the classic inhibitor of mTOR, rapamycin or its analogue CCI-779, can alleviate severity of Huntington-like phenotype in behavioral experiments and facilitate the clearance of mHTT aggregates in a mouse model of HD [173], and co-treatment of rapamycin and trehalose in mice has a synergistic effect on the induction of autophagy which may accelerate the degradation of these aggregate-prone proteins efficiently [198].