The genetic mutations such as superoxide dismutase 1 (SOD1), TAR DNA-binding protein 43 (TDP-43) and Chromosome 9 open reading frame 72 (C9ORF72), fused in sarcoma/translocated in lip sarcoma (FUS/TLS) resulting in accumulation of misfolded proteins have been linked to the disease [209]. Here, SOD1 is linked to sarcoma.