As representative candidate drugs for PD, resveratrol [160] and curcumin [161] have been reported to promote the degradation of α-synuclein by AMPK-SIRT1-autophagy pathway and mTOR/p70S6K signaling pathway respectively, both of them ameliorate the neurodegenerative pathology in cell models of PD. Here, SIRT1 is linked to Parkinson disease.