MCOLN1 and Alzheimer disease: Overexpression of TRPML1 not only decreases the expression of Beclin1, LC3 and LAMP1, but further reduces cell viability and lysosomal ion concentration which have been impaired by Aβ1-42 [99].The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor which recruits PI3K through adaptor DAP 10 and promotes late-onset AD.