The response of Krt76−/− mice to carcinogen included an exacerbated induction of inflammatory cytokines and enhanced accumulation of Tregs in the tumour microenvironment, leading to a drop in anti-tumour response correlated with an exaggerated suppression of the anti-tumour-associated antigen-reactive and increased epithelial cell proliferation (Figure 1, Krt76−/−). Here, KRT76 is linked to neoplasm.