In particular, tumour cells can evolve mechanisms which actively induce T-cell apoptosis, by up-regulating the expression of pro-apoptotic molecules on their surface, such as Galectin-1 25, TRAIL (TNF-Related Apoptosis-Inducing Ligand) 26 and Fas Ligand (FasL) 27, which promote T-cell death by interacting with the corresponding receptors on T-cell surface. Here, TNFSF10 is linked to neoplasm.