Towards this goal, we explored the therapeutic value of a small chemical LRH-1 agonist codenamed BL001 in three different mouse models of T1DM: the RIP-B7.1 mouse in which experimental autoimmune diabetes is induced by immunization (IMM) with the preproinsulin cDNA, the spontaneous and random non obese diabetic (NOD) mouse and the streptozotocin (STZ)-induced diabetes mouse model. The gene discussed is INS; the disease is type 1 diabetes mellitus.