A study conducted by Rosenfeldt, et al. has demonstrated that deletion of autophagy related genes (ATG), Atg5 and Atg7 in KRAS driven mouse models of pancreatic ductal adenocarcinoma, impedes progression of precursor lesions such as pre-malignant intraepithelial neoplasia (PanINs) to a late stage malignant tumor [30]. This evidence concerns the gene KRAS and cancer.