FOXO3 and colon adenocarcinoma: In skeletal muscle, autophagy is also activated by the inactivation of Akt that inversely regulates FoxO3-mediated upregulation of autophagy-related gene expression in response to denervation or starvation 18, 42, or by AMPK-mediated activation of FoxO3 in response to C26 colon adenocarcinoma 43.