SRPK1 and cancer: We utilized a high throughput sequencing approach to characterize the shRNAs present in each compact colony and identified eleven unique shRNA-targeted genes (ACTB, ACTC1, APBA2, C14orf142, KB-1460A1.5, KDELR3, KIAA0922, KIF3B, NR2F1, SRPK1, and TMEM229B) whose expression is associated with in vivo cancer cell motility.