In Drosophila, like Tl and Myd88 deficiency, depletion of Hpo or Warts (Wts, Drosophila homolog of LATS1/2) in fly fat bodies, as well as overexpression of Yorkie (Yki, Drosophila homolog of YAP), causes higher sensitivity to bacterial and fungal infection 72. Here, LATS1 is linked to fungal infectious disease.