YAP1 and fungal infectious disease: In Drosophila, like Tl and Myd88 deficiency, depletion of Hpo or Warts (Wts, Drosophila homolog of LATS1/2) in fly fat bodies, as well as overexpression of Yorkie (Yki, Drosophila homolog of YAP), causes higher sensitivity to bacterial and fungal infection 72.