CD36 and leukemia: Similar to the traits we have identified in CD36+ metastatic-initiating cells of solid tumors 13, chemotherapy-resistant leukaemia stem cells remain quiescent when bound to the adipose tissue, secrete pro-inflammatory cytokines such as TNF-alpha and IL-1alpha to stimulate lipolysis in gonadal adipocytes, and up-take and oxidize the released free fatty acids through CD36 27.