ACSS2 and breast cancer: Other inhibitors such as those targeting the Acetyl-CoA Synthase (ACS), which is involved in fatty acid oxidation and is highly expressed in aggressive tumours, or the activity of Monoacylglicerol lipase (MAGL), which releases fatty acids from lipid reservoirs and is associated with breast cancer aggressiveness, have not been directly tested for their anti-metastatic effect, but show very promising anti-tumour activities 26.