Several tumor suppressors and oncogenes have been identified as direct regulators of the IP3R, whereby tumor suppressors (like BRCA1, PTEN, PML) and oncogenes (like Bcl-2, PKB/Akt) that respectively promote and suppress the activity of IP3R channels by impacting their gating and consequently their open probability 10, 21. This evidence concerns the gene PML and neoplasm.