Four articles with more than 100 citations are “Selenium, the thyroid, and the endocrine system”, “Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations”, “The impact of iron and selenium deficiencies on iodine and thyroid metabolism: biochemistry and relevance to public health” and “Targeted Disruption of the Type 1 Selenodeiodinase gene (Dio1) Results in Marked Changes in Thyroid Hormone Economy in Mice”. The gene discussed is TPO; the disease is autoimmune thyroid disease.