For example, blockade of mIL‐6R might exacerbate asthma symptoms because it releases the inhibitory effect of IL‐6 on dendritic cell‐mediated T cell activation.43 We hypothesise that inhibition of this and other anti‐inflammatory effects of IL‐6 might partly explain why TCZ did not attenuate allergen‐induced bronchoconstriction in our clinical trial. The gene discussed is IL6; the disease is asthma.