⬆ M2 macrophage polarization ⬇ Levels of pro-inflammatory cytokines such as IL-6, iNOS and TNF-α⬆ Expression of anti-inflammatory cytokines (IL-4, IL-10 and TGF-β)⬇ Expression and nuclear translocation of NF-κB p65⬇ Inflammatory response in a vitamin D3-induced rat coronary atherosclerosis model. The gene discussed is IL4; the disease is coronary atherosclerosis.