The anti-inflammatory effect of UA in HFD-induced obese rats [121, 122], inhibition of lipoxygenase-1- (LOX-1-) mediated ROS generation and NF-κB activation as well as atherosclerosis development in mice [123], inhibition of matric metalloproteases in the aortic smooth muscle cells [124], cytokine-induced glioma cell invasion in the transwell cell migration assay [125], or cytokine expression in a macrophage and inhibition of atherosclerosis in mice [126] have also been shown. The gene discussed is NFKB1; the disease is atherosclerosis.