As shown in Figure 6, 25–50 μM NaHS decreased ROS levels and increased phosphorylations of PI3K, AKT, and mTOR, while 200 μM NaHS showed opposite effects, indicating that exogenous H2S regulates the proliferation, viability, migration, and invasion of human thyroid carcinoma cells through the ROS/PI3K/AKT/mTOR signaling pathway. This evidence concerns the gene AKT1 and thyroid gland carcinoma.