Tao Yang et al. [79] reported that emodin could restore the behavioral disorders and abnormal electroencephalogram (EEG) changes in epileptic rats by attenuating the expressions of multidrug resistance gene 1 (MDR1), cyclooxygenase-2 (COX-2), N-methyl-D-aspartate (NMDA) receptor, and P-glycoprotein [79–83]. The gene discussed is PTGS2; the disease is Atypical behavior.