P2RX7 and depressive disorder: In addition, Kai Zhang et al. [78] suggested that CHR alleviated the inflammation of LPS-induced depression rats via reducing the levels of IL-1β/6 and TNF-α and attenuated the expression of P2X7/NF-κB pathway related proteins including P2X7, p-IKKα, p-IKKβ, p-IκBα, and p-NF-κBp65.