By combining the 0.43-0.78 MoM level for PAPP-A (Node 2) with the ≤ 0.5 MoM (Node 5) and > 1.05 MoM (Node 7) for β-hCG, It was shown that all pregnancies were normal in node 5 and 92.6% were DS pregnancies in node 7. The gene discussed is PAPPA; the disease is Dravet syndrome.