Filaggrin mutations, i.e. FLG deficiency is also associated with various skin diseases (ichthyosis vulgaris, eczema herpeticum, atopic dermatitis, periodic infection with Staphylococcus aureus, allergy to nickel, allergic contact dermatitis in combination with AD, eczema, etc.)but also non-skin diseases (e.g. asthma in combination with AD, peanut allergies, allergic rhinitis, diabetes) (30). This evidence concerns the gene FLG and period of infection.