IGHE and allergic disease: Jin et al. (2010) reported thathyaluronidase is a minor yellow jacket venom allergen and onlyaboutb10% to 15% of patients with yellow jacket allergy wasestimated to possess IgE against the hyaluronidase protein 131 .Component-resolved diagnosis with antigen and phospholipasedetect all patients to have yellow jacket venom allergy.