CGRP is released when meninges and meningeal afferents are stimulated (Hanko et al., 1985, Goadsby et al., 1988, Zagami et al., 1990, Cathcart et al., 2010), and intravenous infusion of CGRP can induce migraine-like attacks in migraineurs (Lassen et al., 2002, Lassen et al., 2008, Durham, 2004, Rudolf et al., 2005, Hansen et al., 2010, Deen et al., 2017). This evidence concerns the gene CALCA and migraine disorder.